I found this article awhile back regarding the use of sans serif and serif fonts.
http://www.alexpoole.info/academic/literaturereview.html
Although sans-serif fonts are widely regarded in its use in webby stuff, that doesn’t mean that a serif font can’t work as well toward building highly legible sites.
The conclusion is obvious – use type appropriately based on your needs.
Other useful references:
- http://www.asktog.com/readerMail/2000-01ReaderMail.html#Anchor8
- http://www.ilovetypography.com
- http://www.sitepoint.com/blogs/2008/07/30/custom-web-fonts-pick-your-poison/
- http://www.likewowonline.net/web/ued/sifr-usability-study.html
Other issues regarding font-use:
- legibility vs. readability
- dyslexia / accessibility
- aesthetics
- technical boundaries
- custom fonts
- internationalization